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Insight into the role of cholesterol in modulation of morphology and mechanical properties of CHO-K1

Lei Zhang, Lisha Zhao, Ping-Kai Ouyang, Pu Chen

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 98-107 doi: 10.1007/s11705-018-1775-y

Abstract: However, the effect of cholesterol depletion on the eukaryotic cell membranes seems controversial.In this study, the effects of cholesterol on the topography and mechanical behaviors of CHO-K1 cellsHere, we found that the depletion of cholesterol in cell membranes could increase the membrane stiffness, reduce the cell height as well as promote cell retraction and detachment from the surface, whereascyclodextrin levels and incubation time could significantly increase Young’s modulus and degree of stiffing on cell

Keywords： cholesterol     methyl-β-cyclodextrin     atomic force microscopy     Young’s modulus     CHO-K1 cell    

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High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 376-380 doi: 10.1007/s11705-015-1531-5

Abstract: The Chinese Hamster Ovary (CHO K1) cell was used to express a targeted anti-cancer monoclonal antibodyby optimizing the platform of the construction of production cell line in this study.The adherent CHO K1 was first adapted to suspension culture in chemical defined medium.The best cell pool of CHO K1/IgG1 was used to screen the top single clone using the limiting dilutionFinally, a high IgG1 production of 780 mg/L was obtained from a batch culture.

Keywords： Chinese hamster ovary (CHO)     monoclonal antibody     IgG1     amplification     cell line development    

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New Monitoring Technologies for Overhead Contact Line at 400 km·h−1

Chul Jin Cho, Young Park

Engineering 2016, Volume 2, Issue 3,   Pages 360-365 doi: 10.1016/J.ENG.2016.03.016

Abstract: developed for high-speed railways, in order to boost commercial speeds from 300 km·h−1to 400 km·h−1.Among these technologies, this paper introduces the 400 km·h−1 class currentadopted to inspect the stability of overhead contact line (OCL) components at 400 km·h−1<

Keywords： High-speed railway     Overhead contact lines     Condition monitoring     Image processing based measurement    

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Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: (HIF-1α) and transferrin receptor (TfR).The EGFR/PI3K/AKT signaling pathway was required for the induction of HIF-1α and TfR expression inducedPI3K inhibitors, LY294002 and wortmannin, inhibited HIF-1?In contrast, DEC1 (+/+) HaCat cells strongly enhanced TfR and HIF-1?We conclude that UVB induces TfR and HIF-1αexpressions via EGFR/PI3K/AKT/DEC1 signaling pathway.
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Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan

Qiaomei RU, Younghee CHO, Qingrong HUANG,

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4,   Pages 399-406 doi: 10.1007/s11705-009-0253-y

Abstract: -Carrageenan and -lactoglobulin (-lg) stabilized oil-in-water (O/W) emulsions, which can be used for the oral administration of bioactive but environmentally sensitive ingredients, have been successfully prepared. The effects of protein/polysaccharide ratios, total biopolymer concentration, environmental stress (thermal processing and sonication), and pH on the complex formation between -carrageenan and -lactoglobulin have been investigated. We found that -lactoglobulin and-carrageenan stabilized emulsions can be formed at pH values of 6.0, 4.0, and 3.4. However, the microstructures of emulsions stabilized by -lactoglobulin and -carrageenan was identified by optical microscopy, and it indicated that the emulsion prepared at pH 6.0 flocculated more extensively, while its hydrodynamic radius was much bigger than those prepared at pH 4.0 and 3.4. Regarding rheological properties, the emulsion of pH 6.0 showed a more solid-like behavior but with a lower viscosity than those of pH 4.0 and 3.4. The optimum concentration ranges for -lg and-carrageenan to form stable emulsions at pH 4.0 and 3.4 were 0.3wt-%―0.6wt-% and 0.4wt-%―0.7wt-%, respectively.
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Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which isa cell surface receptor expressed on monocytes/macrophages and neutrophils.TREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway.Soluble TREM-1 (sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluidsand well-known biomarker for infectious diseases. sTREM-1 level can be potentially used for the early

Keywords： soluble triggering receptor expressed on myeloid cells-1     infectious diseases     diagnosis and prognosis    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: for developing more effective therapies that target highly tumorigenic and drug-resistant cancer stem celldemonstrate that a subset of cancer cells with CSC properties may be enriched into tumor spheroids under stem cellconditions from a non-small cell lung cancer cell line.Treating these CSC-like cells with gemcitabine alone and a combination of gemcitabine and the novel CHK100477736 enhances the anti-proliferative effect of gemcitabine against both the parental and the CSC-like cell

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 197-203 doi: 10.1007/s11684-009-0036-3

Abstract: The mRNA and protein expression of phosphatase of regenerating liver 1 (PRL-1) and phosphatase of regeneratingliver 3 (PRL-3) in transitional cell carcinoma of bladder (BTCC) and normal epithelia of bladder wasThe expression of PRL-1 and PRL-3 mRNA was detected by using reverse transcription polymerase chain reactionA significantly positive correlation was found between PRL-1 and PRL-3 in BTCC ( <0.05).PRL-1 and PRL-3 are expressed consistently and may contribute to the growth, differentiation, invasion

Keywords： transitional cell carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regenerating    

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Materials Design on the Origin of Gap States in a High-κ/GaAs Interface Article

Weichao Wang,Cheng Gong,Ka Xiong,Santosh K.C.,Robert M. Wallace,Kyeongjae Cho

Engineering 2015, Volume 1, Issue 3,   Pages 372-377 doi: 10.15302/J-ENG-2015052

Abstract: Our study shows that As−As dimer bonding, Ga partial oxidation (between 3+ and 1+) and Ga&minus

Keywords： high-mobility device     high-&kappa     /III-V interface     interfacial gap states     first-principle calculations    

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Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

Frontiers in Energy 2009, Volume 3, Issue 4,   Pages 414-422 doi: 10.1007/s11708-009-0038-5

Abstract: An axial-type fan that operates at a relative total pressure of 671Pa and a static pressure of 560Pa with a flowrate of 416.6m/min is developed using an optimization technique based on the gradient method. Prior to the optimization of the fan blade, a three-dimensional axial-type fan blade is designed based on the free-vortex method along the radial direction. Twelve design variables are applied to the optimization of the rotor blade, and one design variable is selected for optimizing a stator which is located behind the rotor to support a fan-driving motor. The total and static pressure are applied to the restriction condition with the operating flowrate on the design point, and the efficiency is chosen as the response variable to be maximized. Through these procedures, an initial axial-fan blade designed by the free vortex method is modified to increase the efficiency with a satisfactory operating condition. The optimized fan is tested and compared with the performance obtained with the same class fan to figure out the optimization effect. The test results show that the optimized fan not only satisfies the restriction conditions but also operates at the same efficiency even though the tip clearance of the optimized fan is greater than 30%. The experimental and numerical tests show that this optimization method can improve the efficiency and operating pressures on axial-type fans.

Keywords： axial-type fan     gradient method     free-vortex method     design variable     total pressure     static pressure     operating flowrate    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is one of the most dangerous hematological malignancies,More than 60% of T-ALL patients carry NOTCH1 gene mutations, leading to abnormal expression ofWe found that chidamide, an HDAC inhibitor, exerts an antitumor effect on T-ALL cell lines and primarycells including an anti-NOTCH1 activity.form of NOTCH1 (NICD1) as well as MYC, partly through their ubiquitination and degradation by the proteasome

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 384-389 doi: 10.1007/s11684-009-0070-1

Abstract: In the present report, cyclin-dependent kinase1 (CDK1) siRNA was transfected into cells to silence theCDK1 gene expression and study its role in the cell cycle and cell apoptosis.The cell cycle was analyzed by using DNA content analysis by flow cytometry.Cell apoptosis was detected by the Annexin V/PI method.The decreased CDK1 expression by siRNA silencing gave rise to cell cycle arrest in G/M phase but did

Keywords： cyclin-dependent kinase1     siRNA interference     cell cycle     apoptosis    

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Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 374-379 doi: 10.1007/s11684-008-0072-4

Abstract: Expression of DNA methyltransferase 1 (DNMT1), which plays an important role on aberrantly methylatedinhibitory rates of DNMT1 mRNA levels in T24 cells were 28.44%, 52.48%, 70.91%, respectively.Those of DNMT1 proteins were 24.27%, 57.79%, and 77.74%, respectively.The growth inhibition rates of pshRNA-DNMT1 at the 24th, 48th and 72nd hour after transfection of pshRNA-DNMT1of bladder cancer cell and promote the cellular apoptosis.
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Preliminary experimental study of a supercritical CO

Junhyun CHO, Hyungki SHIN, Jongjae CHO, Young-Seok KANG, Ho-Sang RA, Chulwoo ROH, Beomjoon LEE, Gilbong

Frontiers in Energy 2017, Volume 11, Issue 4,   Pages 452-460 doi: 10.1007/s11708-017-0504-4

Abstract: Research on applying a supercritical carbon dioxide power cycle (S-CO ) to concentrating solar power (CSP) instead of a steam Rankine cycle or an air Brayton cycle has been recently conducted. An S-CO system is suitable for CSP owing to its compactness, higher efficiency, and dry-cooling capability. At the Korea Institute of Energy Research (KIER), to implement an S-CO system, a 10 kWe class test loop with a turbine-alternator-compressor (TAC) using gas foil bearings was developed. A basic sub-kWe class test loop with a high-speed radial type turbo-generator and a test loop with a capability of tens of kWe with an axial type turbo-generator were then developed. To solve the technical bottleneck of S-CO turbomachinery, a partial admission nozzle and oil-lubrication bearings were used in the turbo-generators. To experience the closed-power cycle and develop an operational strategy of S-CO operated at high pressure, an organic Rankine cycle (ORC) operating test using a refrigerant as the working fluid was conducted owing to its operational capability at relatively low-pressure conditions of approximately 30 to 40 bar. By operating the sub-kWe class test loop using R134a as the working fluid instead of CO , an average turbine power of 400 W was obtained.

Keywords： supercritical CO2     power cycle     turbomachinery     compressor     turbine    

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Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that Review

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Engineering 2023, Volume 20, Issue 1,   Pages 9-18 doi: 10.1016/j.eng.2022.05.014

Abstract:

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) is a multifaceted intracellular proteinIts murine homologue, T-cell death-associated 51 (TDAG51) gene, was initially discovered forits role in activation-induced apoptosis in T-cell hybridomas.In recent years, PHLDA1 has received increased attention due to its association with obesity, fatty liverendoplasmic reticulum stress signaling pathways as a crucial mediator of apoptosis, autophagy, and cell

Keywords： ER-stress     Metabolism     Apoptosis     Cell survival     PHLDA1    

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Title Author Date Type Operation

Insight into the role of cholesterol in modulation of morphology and mechanical properties of CHO-K1

Lei Zhang, Lisha Zhao, Ping-Kai Ouyang, Pu Chen

Journal Article

High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

Journal Article

New Monitoring Technologies for Overhead Contact Line at 400 km·h−1

Chul Jin Cho, Young Park

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Journal Article

Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan

Qiaomei RU, Younghee CHO, Qingrong HUANG,

Journal Article

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Journal Article

Materials Design on the Origin of Gap States in a High-κ/GaAs Interface

Weichao Wang,Cheng Gong,Ka Xiong,Santosh K.C.,Robert M. Wallace,Kyeongjae Cho

Journal Article

Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Journal Article

Effect on proliferation and apoptosis of T24 cell lines via silencing DNMT1 with RNA interference

ZHANG Shilong, ZENG Fuqing, PENG Shibo, WANG Liang

Journal Article

Preliminary experimental study of a supercritical CO

Junhyun CHO, Hyungki SHIN, Jongjae CHO, Young-Seok KANG, Ho-Sang RA, Chulwoo ROH, Beomjoon LEE, Gilbong

Journal Article

Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1): A Multifaceted Cell Survival Factor that

Tamana Yousof, Jae Hyun Byun, Jack Chen, Richard C. Austin

Journal Article